9/12 Statistics Seminar: Susanne May, PhD

September 12, 2012
12-1 pm with coffee social prior
GMCS 405

Susanne May, PhD
Department of Biostatistics
University of Washington

Pooling and Futility Boundaries

In this talk work on two very different applied statistical topics will be discussed. One relates to analysis approaches involving pooled samples. This work was motivated by data that are used to monitor virologic failure among HIV-infected patients receiving antiretroviral therapy. Previous analyses of pooled data have primarily considered dichotomous outcomes (such as diseased/non-diseased). We present a number of analysis strategies that incorporate the use of quantitative measures and evaluate their performance. The other work relates to potential dangers of inappropriate futility boundaries in the setting of group sequential trials. This work is motivated by clinical trials that are performed under exception from informed consent.


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