Statistics Seminar: Scott Bartell, PhD

Statistics Seminar

Wednesday, September 26, 2012
12-1 pm with coffee social prior
GMCS 405


Scott Bartell, PhD
Department of Epidemiology and Department of Statistics
UC Irvine

Use and Misuse of Exposure Biomarkers in Epidemiology

Validated exposure biomarkers are often treated as “gold standards” for exposure classification in epidemiologic studies. However, established biological theory and empirical evidence indicate that most biomarkers and exposures are time-varying, and that biomarkers are less useful for classifying historical exposures than recent exposures. ¬†Instead, I propose Bayesian and frequentist methods that link biomarker measurements to latent exposure variables using established pharmacokinetic models. ¬†An investigation of perfluorooctanoate (PFOA) exposure and pregnancy outcomes among 11,737 participants in the C8 Health Project is used as a case study.


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